evaluating the effects of medication on the eses patterns and autism traits in non-epileptic children with asd in bandar abbas, iran

Background: autism is a disorder that affects brain development, causing difficulties in social interaction, communication, and interests. eses is a sleep-related condition linked to autism. this study examines the epileptic conditions in autistic children, their clinical response, and brain wave normalization following medication treatments.methods: this clinical trial was conducted on children with autism who had initial eeg abnormalities during sleep. the children were divided into three distinct groups, each administered different medications. a pediatric neurologist monitored the children's autistic symptoms using eses assessments over a period of 6 months. ultimately, the effect of different medications on improving the children's autistic symptoms and eeg patterns was evaluated.result: out of the 29 patients who participated in this study, 6 (20.7%) were completely removed from the autism spectrum, 21 (72.4%) showed a clinical response of more than 50%, and 2 (6.9%) did not show any clinical response. additionally, the group administered sodium valproate showed the greatest improvement compared to the other groups. regarding the final eeg results, 3 cases (10.3%) showed complete normalization, 24 cases (82.8%) exhibited suitable changes, and 2 cases (6.9%) remained unchanged. however, these changes were not statistically significant.conclusion: this study demonstrated that sodium valproate and corticosteroids can improve eeg alterations in eses and, as a result, reduce children's autistic symptoms. however, due to the lack of statistical significance in the data, it is suggested that additional trials with larger sample sizes and longer follow-up periods be conducted to obtain more reliable results.