Association between TNFα-308 G/A and IFN-γ + 874A/T Polymorphisms with Oral Lichen Planus

Background: oral lichen planus (olp) is a chronic disease that presents with inflammation and has a global prevalence of 0.1-4%. lesions of the disease occur in the oral mucosa, gums, and rarely in the palate. this study aimed to investigate the relationship between this disease and tnfα-308g/a and ifn-γ + 874a/t polymorphisms. methods: in this case-control study, oral mucosal samples were collected from 50 healthy subjects, and 50 olp patients presented to the kerman faculty of dentistry were enrolled using a simple sampling method. subsequently, we used the amplification refractory mutation system polymerase chain reaction (arms-pcr) technique followed by sequencing to determine the presence of tnfα- 308g/a and ifn-γ + 874a/t polymorphisms in cases and controls. results: compared to the control group, the prevalence of a and ga alleles of the tnf gene was higher than the prevalence of g and gg alleles in olp patients, while the aa genotype of the gene was not found in olp patients. regarding ifn gene polymorphism, the relationship between the t allele and the risk of disease was discovered, but it was not statistically significant (p value: 0.068). conclusion: although there is a strong relation between the a allele of tnf-α (-308g/a) polymorphism and the risk of olp, this association between ifn-γ + 874a/t genotype and the disease was not strong enough to predict the possibility of developing olp.