Association of Polymorphisms in IL-10, TGF-β1, IFN-γ, and TNF-α Genes with the Susceptibility to Chronic Obstructive Pulmonary Disease in Kerman, Iran

Background: one of the principal cigarette smokes (cs) mediated diseases is chronic obstructive pulmonary disease (copd). methods: in the current case-control study, the relationship between the polymorphisms of interleukin-10 (il-10), transforming growth factor-β1 (tgf-β1) codon 10, tgf-β1 codon 25, interferon-γ (ifn-γ), and tumor necrosis factor-α (tnf-α) in 213 individuals with copd and susceptibility to the disease, with 100 healthy age and gender-matched people as a control group, was investigated using pcr-arms (polymerase chain reaction-amplification refractory mutation system). moreover, the combination of the polymorphisms of tgf-β1 codon 10.25 regarding this susceptibility was studied in the same condition. results: there was a significant difference between polymorphism of tgf-β1 codon 10 ( + 869 t/c), codon 25 (g + 915c), and susceptibility to the disease (or = 0.50; (95 %ci = 0.24-1.07, p = 0.05), or_cc = 5.31; (95% ci: 1.22-23.2); p = 0.02), thus polymorphism of il-10 and tgf-β1 increased the risk of susceptibility to copd but the polymorphisms of tnf-α (g-308a) and ifn-γ ( + 847 t/a) did not show any association. conclusion: all in all, it is recommended that the patients carrying the above-said genotypes should be paid proper attention, especially those who are exposed to chemicals at their workplaces, pollution, and cigarette smoke.