association of changes in liver enzymes, serum albumin and renal function tests with covid-19 disease severity: a retrospective single-center study from hamadan

Background: the outbreak of the covid-19 pandemic started in wuhan, china, in december 2019 and spread rapidly around the world. effective indicators to evaluate the severity and clinical progress of the disease need to be further investigated so that they can be used to reduce mortality. we sought to analyze the laboratory findings of some cases of coronavirus pneumonia in iran.methods: this was a retrospective study of patients hospitalized with confirmed covid-19 at sina hospital, affiliated with hamadan university of medical sciences, between march 20, 2020, and june 21, 2021.results: the mean age of the 1400 patients was 57.2±16.18 years, of which 64.2% (896 patients) were over 50, 52.6% were men, and 85.95% were in the critical group. a total of 508 patients (78.0%) had hypoalbuminemia. creatinine and blood urea nitrogen (bun) levels increased in 16.2% and 12.5% of patients, respectively. regarding liver enzymes, 27.7% of patients had an increase in the alanine aminotransferase (alt) enzyme, and 46.3% also showed an increase in the aspartate aminotransferase (ast) enzyme.conclusion: a decrease in serum albumin, increased liver enzymes, and changes in kidney function tests were observed in patients with coronavirus. moreover, it was found that these changes were associated with inflammatory markers. screening and daily monitoring of patients lead to early identification of risk factors in patients.