Evaluation of rs37464444 Polymorphism of miR-499 Gene in Patients with Colon Cancer Compared with Healthy Subjects

Background: single nucleotide polymorphisms (snps) have been introduced as a new genomic source for cancer. therefore, it was decided to conduct a study to evaluate the rs3746444 polymorphism of mir-499 in patients with colon cancer in comparison with healthy subjects.methods: this case-control study was conducted to investigate rs3746444 polymorphism of mir-499 in blood samples of case and control groups. patients with a confirmed diagnosis of cancer based on pathologic report were enrolled in the study as the case group and compared with healthy subjects. the level of significance was considered at p< 0.05.result: the mean of dna count in samples was 63.17± 23.51 that was significantly higher in the case group. the rs3746444 polymorphism of mir-499 was significantly higher in patients with cancer compared to the healthy subjects (p < 0.05).conclusion: in this study, rs3746444 polymorphism of mir-499 was significantly higher in patients with colon cancer, which indicated that people with this polymorphism had a higher risk for malignancy.