the effect of silk-nanocefixime suture on healing and antibacterial properties

Background: surgical sutures are sterile filaments to support the healing process. also suture as a major part of surgical site management can challenge surgical wound healing. the objective of the current study was to prevent surgical site infection by creating a new antibacterial silk-nano cefixime suture. methods: the silk suture became silk-nano cefixime suture by immersing in the 1, 2, and 3 wt % cefixime solutions. the antibacterial activity of silk-nano cefixime suture was tested on e. coli (atcc25922). the healing effect of silk-nano cefixime suture was evaluated by h&e staining sections and compared between the control and treated groups on days 3, 8 and 14. the obtained quantitative data were presented as mean ± standard deviation. in order to compare the mean of quantitative variables between the studied groups, general linear model of statistical analysis test and 3-d spss charts were used (p ≤ 0.05). results: the inhibition zone diameter of e. coli (atcc25922) was 25 mm and no statistically significant difference was found between the healing properties (p≥.05). there was a significant difference in the mean of polymorphonuclear leukocytes (pmn) and macrophage infiltration between the control and treated groups on day 8 (p≤ 0.05). conclusion: our data indicate that silk-nano cefixime suture has the potential to reduce the risk of surgical site infections. finally, it is strongly recommended to introduce silk-nano cefixime suture as a reliable substitute for current surgical sutures.