increased risk of hypertension in low aged-carriers with rs2596542 risk-allele

Hypertension with its related disorders is one of the most common health problems among the iranian population. hypertension can be developed by chronic stress and a positive association between stress and rs2596542 has been confirmed. a total number of 112 hypertensive patients and 97 healthy individuals were involved in the study. total blood genomic-dna was extracted and pasa (pcr amplification of specific alleles) method was used to amplify mica-rs2596542 polymorphic site. different genotypes were visualized. the normality of the data was assessed and the binary logistic regression was used for or and 95%ci calculations. a-risk allele of rs2596542 increased the risk of hypertension development significantly (or=1.734, p=0.006). females were significantly more potent to hypertension development than males (or=2.015, p=0.013). risk-allele homozygotes (aa) showed a higher risk of hypertension development than gg (or=2.132, p=0.020) and ag individuals (or=3.206, p=0.006). age adjustments at 70 years old, further increased the risk of hypertension development in gg (or=3.772, p=0.011) and ag (or=6.531, p=0.009) individuals. a-risk allele of rs2596542 could increase the risk of hypertension up to 3.2 folds and this risk could be upraised after sex and age adjustments.