reduction of saliva and serum 25-hydroxycholecalciferol in multiple sclerosis

Methods:the prevalence of multiple sclerosis (ms) is high in patients suffering from 25-hydroxyvitamin d3 [25(oh)d] deficiency. the aim of this study was to investigate the possible association of saliva and serum 25(oh)d concentrations with ms in women. methods: serum and saliva 25(oh)d levels of 30 ms women and 30 matched healthy controls in this case-control study were measured by elisa. data were analyzed by unpaired two-tailed student’s t-test, pearson correlation test and receiver operating characteristic (roc). results: the mean levels of 25(oh)d in serum and in both stimulated and unstimulated saliva were significantly lower in patients with ms. serum levels of 25(oh) significantly correlated with stimulated (r = 0.575; p=0.003) and unstimulated saliva (r = 0.548; p=0.004). the mean (±sd) edss was 3.6±1.9 in the ms group. edss was not significantly correlated with 25(oh)d in serum or in stimulated and unstimulated saliva. the cut-off points of 25(oh)d in serum and saliva were 18 ng/ml and 65 pg/ml, respectively.conclusions:25(oh)d level in saliva like in serum was low in ms women. serum 25(oh)d levels correlated positively with saliva 25(oh)d in women suffering from ms.