evaluation of the optimal dosage for the efficacy of submucosal midazolam administration to induce sedation in children undergoing diagnostic procedures

<strong>background:</strong> preservation of sedation is vital and of great significance to successfully carry out diagnostictherapeutic procedures in children and researchers believe that it is indispensable to offer a safe medication with appropriate administration in this regard. hence, the present study aimed at evaluating the efficacy of different doses of submucosal midazolam to induce sedation in children undergoing diagnostic procedures.<strong>methods:</strong> the present study was a clinical trial, in which 99 patients undergoing diagnostic procedures within the age range of 3 months to 5 years were selected and divided into three groups (n=33) of receiving submucosal midazolam administration with doses of 0.3, 0.4, and 0.5 mg/kg. then, the onset time of sedation, level of sedation, and duration of drug action were recorded and compared among the three groups.<strong>results:</strong> in the present study, the level of sedation 30 min after the administration of midazolam 0.3 mg/kg with the mean value of 2.42±0.83 was significantly lower than that of midazolam 0.4 and 0.5 mg/kg with the mean values of 3.51±0.62 and 3.36±0.60, respectively (<em>p</em>value <0.001). however, two doses of 0.4 and 0.5 mg/kg did not differ significantly.<strong>conclusion:</strong> the best submucosal dosage of midazolam for sedation with the least complications for pediatric diagnostic procedures is 0.4mg/kg.