supplementation with omega-3 plus vitamin e and zinc plus vitamin c on metabolic syndrome components in postmenopausal women with type 2 diabetes

The aim of this study was to find the influence of supplementation with omega-3 plus vitamin e and vitamin c plus zinc on metabolic syndrome components. in a double-blind controlled clinical trial, 75 diabetic postmenopausal women were randomly assigned to one of the three therapeutic groups of daily supplementation of 1.8g omega-3 plus 400mg vitamin e (group a), 5mg zinc plus 300mg vitamin c (group b), or placebo (group c) for 12 weeks and the results were evaluated. one-way repeated measures anova showed that systolic and diastolic blood pressure and waist circumference showed significant difference before and after the intervention (p= 0.0001, 0.001, and 0.045, respectively). results of univariate anova showed that the level of plasma fasting blood sugar (fbs) and hdl-cholesterol significantly increased (p=0.01 and p=0.03, respectively) in patients who had been diagnosed as diabetic ≤7 years in group b. the plasma tg concentration significantly decreased (p=0.007) in patients who had been diagnosed as diabetic ≤7 years in group a. systolic and diastolic bp significantly decreased (p=0.005 and p=0.04, respectively) in patients who had been diagnosed as diabetic ≤7 years in group a. the most effectiveness of nutraceutical supplementation was on patients that had been diagnosed as diabetic ≤7 years. plasma tg and systolic bp decreased with omega-3 plus vitamin e; however, plasma fbs and hdl- cholesterol increased with zinc plus vitamin c supplementation. several factors, such as duration of diabetes, age, gender, pathophysiology status, genetic, and other anthropometric characteristics may influence the effectiveness of supplementation.