Snhg6 203 and Snhg6 201 Transcripts Can Be Used As Contributory Factors For A Well-Timed Prognosis and Diagnosis of Colorectal Cancer

Background: long non-coding rnas, as a big part of non-coding rnas, are considered functionally more than past. these transcripts could be involved in carcinogenesis. snhg6, as a long non-coding rna, has been reported to be expressed more in colorectal cancer tissues than non-cancerous ones. colorectal cancer as a malignancy needs fast prognostic and diagnostic methods for well-timed treatment. snhg6 rna and its relative variants can be considered as biomarkers for a well-timed treatment of colorectal cancer. methods: rna extraction from 32 colorectal cancer tissues and their relative non-cancerous tissues were carried out and cdna of the mentioned rnas was synthesized and rt-qpcr was performed. relative expression of snhg6 201 and 203 were studied in colorectal cancer samples with different clinicopathological characteristics. results:the expression patterns of snhg6 201 and 203 variants were different. snhg6 203 was expressed significantly higher in colorectal tumor tissues than non-cancerous ones. in spite of snhg6 203, snhg6 201 was expressed significantly in colorectal non-cancerous tissues more than tumor ones. additionally, expression of these variants in different colorectal cancer cell lines was different. conclusion: it seems that snhg6 203 transcript might be considered as a prognostic and diagnostic biomarker in colorectal cancer case studies and treatments. also, snhg6 201 can distinguish precisely the tumor and non-tumor tissues in colorectal cancer.