the association of 4g/5g polymorphism of pai-1-675 gene with clinicopathologic features of thyroid tumors in iranian azeri turkish patients

Background: due to the lack of information about the role of 4g/5g polymorphism of pai-1 gene in susceptibility to thyroid tumors, this study was performed to evaluate the potential effects of this polymorphism on clinicopathologic features of thyroid tumors in iranian azeri turkish patients. methods: in this case-control study, 90 patients with thyroid tumors who were not blood relatives and their pai-1 4g/5g polymorphism had been determined in the previous study, were included. results: all clinicopathologic features of thyroid tumor related to pai-1 4g/5g polymorphism that affect the severity of disease were studied. the results show that t1 tumor size (4g/4g, p = 0.019; 4g/5g, p = 0.021) in patients with/without these features was significantly different. conclusion: data showed a protective role for 4g allele versus 5g and 4g/4g versus 5g/5g against the development of thyroid tumors in azeri turkish ethnic group.