Determination of Serum Calprotectin, Heparin-Binding Protein, and Some Inflammatory Factors in Patients with COVID-19

Background: among the serum biomarkers of infectious diseases, calprotectin and heparin-binding protein (hbp) seem to be of clinical and diagnostic value in patients with covid-19. objectives: this study aimed to investigate theserumlevels of calprotectin, hbp,andsomeother inflammatory markers in covid-19 patients. methods: in this case-control study, serum samples of 35 outpatients with covid-19 and 35 healthy individuals were collected, and the levels of calprotectin, hbp, c-reactive protein (crp), ferritin (ferr), as well as platelet (plt) and neutrophil (neu) counts and ldh activity, were determined. results: at first, sars-cov2 viral rna was detected in the pharyngeal swab specimens of covid-19 patients. calprotectin, ferr, and crp levels, ldh activity, and plt and neu counts were found to be significantly higher in covid-19 patients compared with controls (p < 0.05), whereas no statistically significant difference was observed in hbp level (p > 0.05). serum calprotectin showed a significant correlation with crp and ferr levels, ldh activity, and neu count (p < 0.001). conclusions: our findings showed that an increment in serum calprotectin level, together with increased crp levels, might be a promising indicator of sars-cov2 infection.