تاثیر هشت هفته تمرینات تناوبی با شدت بالا همراه با مصرف مکمل اسپیرولینا بر تغییرات وزن و شاخص های قندی رت های مسن چاق دیابتی

زمینه و هدف: یک راه حل پیشنهادی برای اضافه وزن و دیابت ناشی از سالمندی، انجام تمرینات ورزشی است. مکمل اسپیرولینا نیز می تواند در کنترل وزن و دیابت موثر باشد. هدف از پژوهش حاضر بررسی اثر هشت هفته تمرینات تناوبی با شدت بالا همراه با مصرف اسپیرولینا بر تغییرات وزن و شاخص های قندی رت های مسن چاق دیابتی می باشد.روش کار: در این پژوهش تجربی، 40 سر رت نر نژاد ویستار 20 ماهه با میانگین وزنی 280-325 گرم پس از خریداری برای 8 هفته با استفاده از رژیم پرچرب محقق ساخته چاق شده و سپس با تزریق درون صفاقیmg.kg1 40استرپتوزوسین دیابتی شدند و در 5 گروه مساوی (کنترل سالم، شم، تمرین، مکمل و تمرین+مکمل) برای 8 هفته، 5 جلسه در هفته، اجرای hiit (با شدت 90%vo2max) و مصرف  اسپیرولینا (.mg/kg50 b.w) پرداختند.یافته ها: تفاوت معناداری در غلظت گلوکز ناشتا، انسولین و مقاومت به انسولین بین گروه های مورد مطالعه وجود داشت (0/0001=p). نتایج آزمون تعقیبی نشان داد hiit و مکمل موجب بهبودهای معناداری در مقادیر این متغیرها نسبت به گروه های کنترل و شم شد. انجام hiit و مصرف مکمل موجب ایجاد تغییرات معناداری در وزن بین گروه های مورد مطالعه شد که پس از آزمون تعقیبی مشخص شد گروه تمرین+مکمل کاهش وزن بیشتری نسبت به گروه کنترل و شم (0/0001=p) داشت.نتیجه گیری: با توجه به نتایج، اجرای hiit و مصرف مکمل اسپیرولینا می تواند بدلیل تعامل عوامل کاهنده قند خون و وزن بدن موجب کنترل دیابت شود و به عنوان راهکار مناسب، بی خطر و جدیدی که دارای اثرات مشترک هستند، مورد توجه قرار گیرند. 

the effect of eight weeks of high-intensity interval exercise with spirulina supplementation on weight changes and glycemic indices in obese elderly diabetic rats

background & aims: obesity leads to increased health risks and increased economic burden. obesity, especially in the long term and visceral type, is the cornerstone of the pathogenesis of diabetes. depending on race and gender, 50 to 90% of type 2 diabetics are overweight and obese, a rate that has been reported to be higher in older patients. the pathophysiological pathways behind this association are complex and ultimately lead to insulin resistance and secondary cell dysfunction. adipose tissue accumulation produces a range of metabolic and hormonal changes that gradually disrupt the insulin signal transduction pathway and manifest as increased insulin resistance in adipose tissue, liver, and skeletal muscle. on the other hand, it should be noted that the reduction of insulin sensitivity at the cellular level is a natural result of aging. one of the most important compensatory mechanisms against insulin resistance is the increase in pancreatic beta cell mass. this increase in pancreatic cells regulates the dynamic balance between neogenesis, proliferation and apoptotic processes in the islets of langerhans, which is agedependent. are, reflects. but genetic predisposition and aging contribute to betacell dysfunction, which, along with chronic glucotoxic and lipotoxic effects, manifests itself in the development of insulin resistance in obese individuals, resulting in impaired glycemic control and diabetes. nowadays, the basic principles of diabetes control are knowledge and awareness, control of diabetes complications, diet, medication and physical activity, which the low cost and nonpharmacological nature of physical activity increase its therapeutic importance. on the other hand, the beneficial effects of exercise on aging and the side effects associated with it are not hidden from anyone. one type of exercise that has been considered in the control and management of diabetes is highintensity interval training (hiit). due to the characteristics of hiit and its effects on glucose, insulin, insulin resistance and weight, it has been considered by researchers today, although the same results are not reported, which requires further studies in this field. dietary supplements, on the other hand, are a form of complementary and alternative therapies that are widely used by the general public, including diabetics. one of the best supplements available is spirulina supplement. spirulina may be helpful in preventing diabetes; because it is low in calories, and contains large amounts of vitamin b1, which improves the metabolism of sugars in the body, it also contains vitamin b2, which helps burn calories, prevents obesity and contains vitamin b6, which is effective in making the hormone insulin in the body. increased inflammation due to aging, which also leads to diabetes, and the antiinflammatory effects of regular physical activity and spirulina supplementation have led researchers to hypothesize that the two may have synergistic effects that could have an optimal effect on reduce obesity and diabetic complications.the aim of this study was to investigate the effect of eight weeks of highintensity interval training with spirulina supplementation on weight changes and glucose indices in obese elderly diabetic rats.methods: this research was of experimental and applieddevelopmental type. for this purpose, 40 old male wistar rats (20 months) with an average weight of 280 to 325 grams were purchased and transferred to the laboratory. then, the standard diet of field rats was calculated and based on that, a highfat diet derived from soybean and animal oil was prepared and used. the rats were on a highfat diet for eight weeks. rats need 10 grams of pellets per 100 grams of body weight per day (standard diet of rats and 1015 ml of water). the composition of rat pellets included carbohydrates: wheat flour, barley, bran and corn. protein included: