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association of cfi gene polymorphism with age related macular degeneration in northwest of iran
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نویسنده
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norouzi neda ,bonyadi mortaza ,babaei esmaeil ,jabbarpour bonyadi mohammad hossein ,javadzadeh alireza
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منبع
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مطالعات علوم پزشكي - 2017 - دوره : 28 - شماره : 4 - صفحه:16 -21
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چکیده
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Background & aims: to investigate the association of cfi p.gly119arg polymorphism with age-related macular degeneration (amd). materials & methods: in this case-control study, the association of p.gly119arg polymorphism in cfi gene was investigated in 65 patients suffering from amd and150 healthy age, sex and ethnicity matched unrelated people as control group. both of the case and control groups were originated from northwest of iran. genotypes of both groups were determined by polymerase chain reaction (pcr) and restriction fragment length polymorphism (rflp). results: investigation of the association of p.gly119arg polymorphism in cfi gene with amd showed that there are no statistically significant differences between patients and controls in genotype and allele frequencies of this polymorphism (p˃0/05). conclusion: our result show that p.gly119arg polymorphism of the cfi gene is unrelated to the susceptibility to amd in northwest of iran.
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کلیدواژه
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amd ,polymorphism ,cfi gene
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آدرس
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university of tabriz, faculty of natural sciences, center of excellence for biodiversity, ایران, university of tabriz, faculty of natural sciences, center of excellence for biodiversity, ایران, university of tabriz, school of natural science, department of animal biology, ایران, shaheed beheshti university of medical sciences and health services, ophthalmic research center, ایران, tabriz university of medical scinces, nikookari eye hospital, department of ophthalmoiogy, ایران
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Authors
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