activity of a novel 2-phenoxy nicotinic acid hydrazide sulfonamide against leishmania tropica

Introduction: cutaneous leishmaniasis is an endemic health problem worldwide. the absence of an alternative chemotherapeutic approach to treating leishmania infection requires urgent attention. so, the laboratory-trial study aimed to determine the activity of a novel 2-phenoxy nicotinic acid hydrazide sulfonamide against leishmania tropica. methods: the different densities (0.2, 1, 5, 25, and 125 μg /ml) of 2-pnahs and glucantime (0.2, 1, 5, 25, and 125 μg /ml) were provided and added to parasite cultures. then, the anti-leishmania activity of the 2-pnahs against glucantime was determined using an in-cell proliferation elisa, brdu (chemiluminescent). results: according to the results, a dose-dependent decrease was observed in the viability of the leishmania (l) tropica promastigotes using glucantime (p<0.05). administration of different levels of the 2-pnahs (0.2, 1, 5, 25, and 125 μg /ml) significantly decreased the leishmania (l) tropica promastigotes (p<0.05). additionally, a difference was detected in the anti-leishmania activity of the 2-pnahs compared to glucantime and the control group (p<0.05). conclusion: these results suggest that 2-pnahs had anti-leishmania activity better than glucantime.