expression of pcgem1 and lincrna-p21 lncrnas in breast cancer tissue

Objectives: long non-coding rnas (lncrnas) play critical roles in tumor development, progression, and prognosis. prostate cancer gene expression marker 1 (pcgem1) is an oncogenic lncrna that inhibits apoptosis, whereas lincrna-p21 promotes apoptosis. this study aimed to investigate the expression of these lncrnas in breast tumor tissue and adjacent non-tumor tissue. methods: the expression levels of pcgem1 and lincrna-p21 were assessed by real-time pcr (rt-pcr) in fifty formalin-fixed, paraffin-embedded invasive ductal carcinoma breast tumor tissues and adjacent non-tumor tissues. results: the expression of pcgem1 was significantly higher in tumor tissues compared to adjacent non-tumor tissues (p=0.01). roc curve analysis indicated that the sensitivity and specificity of pcgem1 for discriminating breast cancer were %60.87 and 70.21%, respectively, with an area under the curve (auc) of 0.63 (p=0.01). no significant correlation was observed between pcgem1 expression and tumor size, histological grade, or lymph node involvement. the expression of lincrna-p21 was similar in tumor tissues and adjacent non-tumor tissues. conclusions:  pcgem1 may contribute to the pathogenesis of breast cancer and could serve as a diagnostic marker in breast cancer.