a review of the therapeutic effects of polyphenols on non-alcoholic fatty liver disease: focus on oxidative stress

A substantial body of research suggests that polyphenols may have health benefits, particularly in metabolic disorders associated with obesity, such as non-alcoholic fatty liver (nafld), type 2 diabetes, and cardiovascular disease. given the importance of oxidative stress in the pathogenesis of metabolic disorders, significant emphasis has recently been placed on the characteristics of polyphenols in obesity-related problems. this narrative review summarizes the current knowledge on the inhibitory effects of polyphenols, including curcumin, resveratrol, baicalin, nobiletin, and quercetin, on oxidative stress, with a focus on the role of the nrf2 pathway. this review compiles the data from articles showing that the aforementioned polyphenols improve health in metabolic diseases by regulating nrf2 and its target proteins involved in reducing oxidative stress. however, due to the limitations of in vitro and in vivo investigations, as well as the lack of long-term human clinical trial studies, further high-quality research is required to definitively demonstrate the clinical usefulness of polyphenols for the prevention and management of nafld.