homeostatic model assessment of β-cell function may be an emerging predictor of bone resorption in metabolically unhealthy obesity

Objectives: the aim of this study is to compare three distinct bone markers in metabolically healthy and unhealthy obese and non-obese subjects, according to various metabolic health criteria. methods: the study enrolled a total of 35 subjects, including 11 healthy normal-weight and 23 obese subjects. based on homa-beta, all participants were divided into three groups: normal weight (hom-beta<100%, n=11), obese (homa-beta <100%, n=12), and obese (homa-beta>100%, n=12). the serum levels of osteocalcin, procollagen i amino-terminal propeptide (p1np), and beta-cross laps as bone turnover markers, as well as serum levels of 25 (oh) vitamin d3, and pth were analyzed. results: significant differences were observed in bmi, age, 25(oh)d3, fbs, insulin, homair, and homa-beta among the groups. analysis of bone markers revealed that the serum levels of beta-cross laps, p1np, and osteocalcin were significantly different among all studied groups categorized by the homa-beta model. in this context, circulating levels of osteocalcin and betacross laps in the normal weight group (homa-beta<100%) were significantly higher than the obese group (homa-beta <100%). in obese patients with homa-beta <100%, beta-cross laps and p1np levels were lower compared to the obese group with homa-beta >100%. conclusion: the data suggests that homa-beta, as an index of β-cell function, can be used in part of metabolically healthy obese (mho) criteria and bone remodeling is altered in the context of metabolically healthy obesity.