mixed-metal cupper-vanadium coordination polymer at bulk and nano scale: biological (antitumor and antimicrobial), structural and thermal properties studies

Anticancer and antimicrobial activity of new one-dimensional mixed-metal cupper-vanadium coordination polymer 〖[cu_2 (2,2΄-bpa)(f_2)〖(-o)〗_2 v]〗_n at bulk and nano-sized have been studied and these new coordination polymers characterized by elemental analysis, ir spectroscopy, scanning electron microscopy (sem), xrd powder diffraction and its structures, studied by single crystal x-ray crystallography. the in-vitro anticancer studies reveal that the mixed-metal cu-v coordination polymers at bulk and nano-sized had the best anticancer activity against mcf-7 (hba = human breast adenocarcinoma) cells with ic50 values of 5.89 μm and 7.90 μm. this coordination polymer effects on the antibacterial activity (against staphylococcus epidermidis (se) atcc 14990, bacillus subtilis (bs) atcc 6633, bacillus cereus (bc) atcc 14579, pseudomonas aeruginosa (pa) atcc 9027 and escherichia coli (ec) atcc 25922 strains).