preparation of curcumin-containing beta cyclodextrin conjugated chitosan multifunctional nanoparticles: improved anti-cancer efficacy

A modified inclusion complex was prepared by chitosan (cs) nanoparticles in acetic acid 1% with cyclodextrin(cds) of beta-cyclodextrin for the sustained and controlled effects of various pharmacology of curcumin (cur). curcumin (cur) has various pharmacological effects, but its extensive first-pass metabolism and short elimination half-life limit its bioavailability. cur-cd was then encapsulated into positively charged biodegradable chitosan (cur-cd-cs) nanoparticles. therefore, transdermal application has become a potential alternative to delivery cur. to increase cur solubility for the development of a transparent homogenous and also enhance the permeation of cur into the cells of body, nanoparticle complex cur/cdscs as drug was developed. the drug bioactivity studies were performed and found that modified complex occurs excellent which is due to cs 1% and diffusion of cur/ beta -cd from cs nanoparticle. the drug characterization data best fitted. antioxidant efficiency of cur/β-cd-cs was found to be 50%. further, the complexed particles possessed significantly ic50 value (0.06mm of cur/β-cd-cs1%) indicating its synergistically enhanced radical scavenging property. the antibacterial carried out using the nanoparticle compound, cur/cds-cs. also cytotoxicity studies cur/cds-cs on a549 cells reveal the advantage of the cur/β-cd over cs nanoparticle compound. overall, cur in the form of the cur/ beta -cd-cs improved the solubility further on the penetration of cur.