an ultra-efficient and reusable nano-bio catalyst for suzuki cross-coupling reaction in aqueous media

Metal-catalyzed cross-coupling reactions are one of the most important tools for the c-x (x: n, s, o, ...) bond formation. the point of metal catalysis was highlighted by the award of the 2010 nobel prize to heck, negishi and suzuki for their remarkable work in this field [1]. several challenges like the limited availability and high price and environmental attention make it vital to improve metal catalysts with the notable properties including the highly active site with excellent recyclability and little metal leaching to reduce the costs and pollutions [2]. herein, a highly active and stable cobalt nano-catalyst was prepared and characterized. initially, a novel nano bio catalyst was successfully prepared, then was functionalized by designed ligands and finally co2+ immobilized on acceptor bed by a simple method for the first time. the nano-catalyst showed great activities in c-c bond formation reaction. extraordinary simplicity, mild reaction condition, excellent yields were some advantages of this protocol. more importantly, this catalytic system is capable to use for the gram-scale synthesis of the desired products (figure 1).