cu(ii)/l-his@fe3o4 supported on magnetic nanoparticles: a highly efficient and recoverable catalysts for organic transformations

Mounting interest is recently expressed for surface functionalization of nanocatalysts in which the nanoscale architecture of active centre plays a dominant role in determining their efficiency and selectivity [1-3]. in this regard, the use of supported magnetic nanoparticles (mnps) materials has been efficiently employed as heterogeneous catalysts. here we prepared a nanocatalyst by immobilization of the cu(ii)-l-histidine complex on magnetic fe3o4 nanoparticles. copper (ii) bound to l-histidine is in equilibrium with human serum albumin and may undergo common exchange which modulates the bioavailability of copper to the cell. cu(ii)/l-his@fe3o4 as a novel, efficient and green nanocatalyst was applied successfully in the synthesis of heterocycliccompounds. the resulted catalyst was used in the synthesis of 2,3-dihydroquinazolin-4(1h)-ones, polyhydroquinolines and 2- amino-6-(arylthio) pyridine-3,5-dicarbonitrile as biologically interesting compounds (scheme 1). the present research is focused on investigation of recycling, reusability and stability of the catalyst in the phase reaction. the cu(ii)/l-his@fe3o4 was used at least six times with comparable activities to that of fresh catalyst. the results of the tga/dtg, eds, xrd, vsm, ft-ir and sem characterization confirmed the structure and composition of the catalyst were stable.