fe3o4@phenyl phosphate creatine nanoparticles: a new convenient catalysis system to aza-michael reaction

Tetrazole compounds are a class of important heterocyclic compounds because these compounds have been applied in various area of chemistry as antiinflammatory [1], antimicrobial [2], antifungal [3], antinociceptive [4] and anticancer [5]. the aza- micheal addition of these tetrazoles to a, b-unsaturated carbonyls represents a powerful synthetic method to functionalize tetrazoles. fe3o4@phenyl phosphate creatine nanoparticles were prepared and used as catalyst for the aza-michael reaction of α, β-unsaturated carbonyl. the catalysis was investigated with useful analyses such as ft‐ir, tga, vsm, sem, tem, xrd, and icp. in addition, it is found that the fe3o4@phenyl phosphate creatine nanoparticles catalyst can be recovered and reused five times without losing activity.