selective and facile synthesis of 2-aminothiophenes using na2cap2o7 as base nano-catalyst

In the study we reported synthesis of 2-aminothiophene derivatives in pure water using nano-structured na2cap2o7. our results indicated that this heterogeneous catalyst performed good selectivity and catalytic activity in the synthesis of substituted 2- aminothiophene through gewald reaction in water. the noticeable benefits of this procedure rely on several factors including: a simple method, mildness conditions, short time of reaction, operational simplicity and low cost.