application of near-infrared responsive nano carrier for controlled drug delivery synthesis, isotherm and kinetic studies

Because of the importance of selecting an appropriate strategy in drug delivery systems, numerous studies and approaches have been performed to support this process. however, there are still major obstacles associated with the targeted drug delivery to cancer tissues. hence, the main focus of this study is to develop the current cancer therapies by using drug delivery systems. to achieve this goal, we have synthesized a near-infrared light responsive drug carrier based on ws2 nano-sheets, which can be a good candidate for applications such as drug delivery vehicle and chemo-photothermal treatments. in this study, a rapid and economy synthesis route was employed to modify the nano-sheets of ws2 with suitable aqueous dispersion. adsorption isotherms data were investigated through langmuir, freundlich, temkin, and redlich–peterson models. the langmuir model showed the highest consistent with the nano-carrier (qmax = 15.87). the evaluation of adsorption kinetic were better expressed by pseudo-second-order kinetic model (r2=0.9998). in-vitro drug release from the produced nano-carrier was performed more rapid and complete in simulated blood fluid (ph=7.4) at 50°c than 37°c. besides, the activity of the nano-carrier product for drug release was also examined under near-infrared light irradiation (at 808 nm, 1.0 w/cm2). the drug release data were investigated through zero-order, first-order, higuchi, and korsmeyer–peppas mathematical models.