effect of cα -methylated residue on the folding behavior of p53 peptide: a molecular dynamics study

Disorders in protein-protein interactions are often the main cause of several diseases, making them attractive as drug targets. one of the cancer- associated protein -protein interactions is the hdm2-p53 complex. over expression of hdm2 disrupts the normal activity of p53, which is commonly seen in cancer cells containing the p53 normal type. disruption of the hdm2-p53 interaction to maintain p53 function is considered a therapeutic approach to cancer treatment. to inhibit unnatural ppis, researchers are always look for strategies that interfere with these interactions. helix mimetics containing cα-methylated residues can be a good inhibitor for p53-hdm2 interaction.