a study on accelerated drug release from in-situ forming implants and the correlation with real-time profiles

Since drug release from in situ forming implant (isfi) typically takes weeks to months, real-time in vitro release testing methods are time-consuming and challenging to evaluate and optimize final formulation during development and quality control in the manufacturing process. therefore, developing an accelerated testing method that can shorten the experiment period attracts attention. the study aimed to accelerate the sustained drug release from isfi using elevated temperatures. drug release from one formulation of poly (lactic-co-glycolic) acid (plga) isfi was evaluated in “real-time” (37 °c) and accelerated (45 °c, 53 °c, and 60 °c). the results obtained from accelerated and sustained release studies were correlated using linear kinetic correlation methods by a computer program. the accelerated release method at 53 °c gave the best agreement with real-time release and describes an accelerated in vitro release testing method to predict the real-time in vitro release of triptorelin acetate isfi.