high-intensity interval training combined with saffron supplementation modulates stress-inflammatory markers in obese women with type 2 diabetes

Introduction: the aim of this study was to investigate the interactive effects of saffron extract supplementation with high-intensity interval training (hiit) on serum levels of stress-inflammatory markers in obese women with type 2 diabetes.method: thirty-two obese women with type 2 diabetes were randomly divided into 4 intervention groups: supplement, hiit +supplement, placebo and placebo+ hiit. the anthropometric and blood characteristics of subjects were evaluated in pre-test and post-test. the method of supplementation was that the supplement group received 100 mg of saffron extract daily. the subjects in the training group also did running on the treadmill in 4 bouts with intensity of 85 to 95% of the maximum heart rate along with 4 periods of active rest at the intensity of 50 to 60% of the maximum heart rate.results: data analysis showed that the effect of time was a significant decrease in serum levels of il-6, nt-probnp, and gdf-15 in the supplement, supplement+ hiit and placebo+ hiit groups (p≤0.05). the results of time × group interaction also showed a significant difference between the groups (p≤0.05). so that the decrease in the levels of stress-inflammatory markers in the supplement+ hiit group had a greater decrease.conclusion: according to the results, it can be reported that hiit and saffron supplementation (combination of both) probably reduces the levels of stress-inflammatory markers such as gdf-15, nt-probnp, and il-6 by reducing fat mass, as well as also improve glucose metabolism and insulin resistance in obese women with diabetes.

high-intensity interval training combined with saffron supplementation modulates stress-inflammatory markers in obese women with type 2 diabetes

introduction: the aim of this study was to investigate the interactive effects of saffron extract supplementation with high-intensity interval training (hiit) on serum levels of stress-inflammatory markers in obese women with type 2 diabetes.method: thirty-two obese women with type 2 diabetes were randomly divided into 4 intervention groups: supplement, hiit +supplement, placebo and placebo+ hiit. the anthropometric and blood characteristics of subjects were evaluated in pre-test and post-test. the method of supplementation was that the supplement group received 100 mg of saffron extract daily. the subjects in the training group also did running on the treadmill in 4 bouts with intensity of 85 to 95% of the maximum heart rate along with 4 periods of active rest at the intensity of 50 to 60% of the maximum heart rate.results: data analysis showed that the effect of time was a significant decrease in serum levels of il-6, nt-probnp, and gdf-15 in the supplement, supplement+ hiit and placebo+ hiit groups (p≤0.05). the results of time × group interaction also showed a significant difference between the groups (p≤0.05). so that the decrease in the levels of stress-inflammatory markers in the supplement+ hiit group had a greater decrease.conclusion: according to the results, it can be reported that hiit and saffron supplementation (combination of both) probably reduces the levels of stress-inflammatory markers such as gdf-15, nt-probnp, and il-6 by reducing fat mass, as well as also improve glucose metabolism and insulin resistance in obese women with diabetes.