salivary biomarkers of oxidative stress in methamphetamine users: a case-control study

Background: methamphetamine abuse, a potent and highly addictive stimulant, continues to be a major concern globally due to its potential harmful effects on the human body. research suggests that methamphetamine use leads to an increase in free radicals and oxidative stress in the body, resulting in various adverse consequences.objectives: this study aimed to compare the levels of oxidative stress biomarkers in the saliva of methamphetamine users versus healthy individuals.methods: a case-control study was conducted involving 36 methamphetamine users and 27 healthy controls recruited from farshchian hospital in hamadan, iran. written, informed consent was obtained from all participants. saliva samples were collected and analyzed for catalase activity, total thiol molecules, and total antioxidant capacity.results: there was no significant difference in the demographic characteristics between the case and control groups. however, the mean total antioxidant capacity in methamphetamine users (0.10±0.01 μmol/ml) was significantly lower than in healthy individuals (0.64±0.12 μmol/ml) (p < 0.001). catalase activity and thiol groups in saliva showed no significant differences between the two groups.conclusion: our findings suggest that long-term methamphetamine use triggers oxidative stress and elevates oxidants in the bodies of users.