combination of n-acetylcysteine and letrozole in induction of ovulation for infertile women with polycystic ovarian syndrome

Background objective: ovulation induction is considered the primary treatment for pcos-related infertility. clomiphene citrate (cc) has usually been employed as the first-line medication, although letrozole has recently gained favor due to its improved efficacy in inducing ovulation. to assess the combination of n-acetylcysteine (nac) and letrozole in the induction of ovulation and the success of pregnancy for infertile polycystic ovarian syndrome patients.materials methods: a double-blind random clinical trial was conducted in babylon governorate between 2023 and 2024, in which all patients referred to our hospital suffered from pcos.results: the size of the follicle in patients treated with letrozole + nac was (16.6±3.3) mm, which was significantly larger than that (15.1±3.9) mm in group b (i.e., those treated by letrozole + placebo) (p=0.004). the induction of ovulation was probably considered in 31 (32.3%) of patients in group a, while it was found in 15 (15.6%) of patients in group b with a significant difference (p=0.006). pregnancy success was significantly higher (p=0.029) in group a than in group b (17 vs. 7), respectively.conclusion: adding n-acetylcysteine to letrozole increased the induction of ovulation and success of pregnancy for infertile polycystic ovarian syndrome patients.