clinicopathological implications of serum level of il-27 in endometrial cancer patients

Background & objective: endometrial cancer (ec) is the most prevalent gynecological malignancy in more developed countries. multiple researches have been done about the role of il-27 in different cancers that suggest a dual role for this cytokine. in the present study, we evaluated the serum level of il-27 in endometrial cancer patients. we also investigated the correlations between serum levels of il-27 and the demographic and clinicopathologic features of the patients. materials & methods: in this case-control study, 65 endometrial cancer patients and 58 sex-age-match healthy controls were investigated. serum levels of il-27 in both cases and the control group were assessed by a reliable and specific sandwich enzyme-linked immunosorbent assay (elisa) kit and results were analyzed with spss. results: we observed that the serum level of il-27 in ec patients was dramatically higher than in the control group (p=0.003). additionally, higher grades of ec (grade ii and iii) showed higher il-27 serum levels compared to the control (p=0.006 and p=0.01 respectively). no significant correlations between serum levels of il-27 and lymph node involvement, tumor stage, tumor size, and demographic features of the patients were detected. conclusion: our results showed that there is a statistically significant difference between serum levels of il-27 in ec patients and controls. therefore, the serum level of il-27 may exert a role in the pathogenesis of endometrial carcinoma, although further studies are needed.