epidemiological and pathological factors in breast cancer patients in tehran-iran: a single-centered, retrospective study

Background & objective: breast cancer has the highest incidence among all cancers, and its incidence is increasing rapidly in many countries worldwide, including iran. in this study, epidemiological and pathological factors were investigated in patients with breast cancer. materials & methods: this cross-sectional study included 476 patients with a confirmed diagnosis of breast cancer in tehran, dr. moini breast clinic, from 2019 to 2021. results: the mean age of the patients was 50.2±11.40 years, of which 80.9% were over 40 years. ductal carcinoma was the most common in terms of histology (81.7%), and most patients had grade ii diseases (63.6%). according to hormonal receptors, 73.8% of women were estrogen receptor-positive, 68.9% were progesterone receptor-positive, and 18.9% were triple-negative. there was a significant relationship between grade and lymph node involvement (p-value = 0.00) and also a significant relationship between metastasis and grade (p-value = 0.00) and between metastasis and lymph node involvement (p-value = 0.00). conclusion: the results of this study show that breast cancer has a high prevalence in iranian women in tehran, mainly in the 4th and 5th decades of life. her-2 (epidermal growth factor 2 receptor overexpression) and triple negatives were the least prevalent subgroups. considering that diagnosis occurs late and approximately 63.6% of patients are in grade 2, it is necessary to implement programs in the field of screening and prevention in the female population of this province.