the pathological characteristics of cervical conization and cervical intraepithelial cancer recurrence rate based on different age groups

Background & objective: immunosuppression, hpv persistence, and smoking are the main-related risk factors of cervical intraepithelial neoplasia (cin) recurrence. however, age as a basic factor may be a main factor related to cin recurrence. therefore, our study aimed to detect the potential role of women's age in cin recurrence. materials & methods: this cross-sectional study was conducted on 329 patients who underwent conization in the gynecology-oncology clinics of arash and imam khomeini hospitals affiliated with tehran university of medical sciences between march 2016 and march 2021. results: totally, 329 cases were enrolled in the study. most women were in their thirties. cin recurrence was about 10.0% (32 cases). the cin recurrence rate was 8.9% in women younger than 30, 10.2% in 30-40, 11.3% in 40-50, and 5.6% in 50–60 decades. there was no significant (p-value=0.802) difference in recurrence rate among age groups. there was a significant (p-value=0.023) difference in the frequency of endocervical involvement regarding age category, women aged 40 to 50 had the most frequent marginal involvement with 26.8%, while there was no significant (p-value=0.802) difference in frequency of marginal involvement regards age category. conclusion: cin cases with age higher than 40 years need to have more caution and tight follow-up visit after conization.