d-dimer, activated partial thromboplastin time, and prothrombin time comparison in different severity levels of covid-19 in pregnancy: a single center study

Background & objective: uncertainties exist about the diagnostic and prognostic role of hemocytometry values in patients with covid-19 especially in pregnancy. this study aims to investigate hemostatic changes in pregnant woman with coronavirus disease (covid-19) and their relationship to disease severity. materials & methods: this research is an analytic observational study with case control design. subject was gathered from hasan sadikin general hospital bandung, indonesia patients' medical records from june 2021 – march 2022. inclusion criteria for this study are all pregnant covid-19 patients with prothrombin time (pt), activated partial thromboplastin time (aptt), and d-dimer examination. the exclusion of this study, all pregnant covid-19 patients without required examination. pt, aptt, and d-dimer were measured by stago kits on a stago automated coagulation analyzer (sta compact max®). data was then analyzed by kruskal wallis with ibm spss statistic 26th with α=0.05. results: statistical analysis shows there’s correlation between different severity levels with d-dimer. this study shows the mean of d-dimer of each severity levels; asymptomatic 4.85 mg/l, mild 2.86 mg/l, moderate 5.47 mg/l and severe 14.51 mg/l (p <0.000). changes seen after mild group which increase to 5.47 mg/dl in moderate covid-19 and furthermore increase in severe become 14.51 mg/l. no changes in pt and aptt were found. conclusion: in conclusion, our findings demonstrate that coagulopathy is associated with the severity of covid-19 illness. d-dimer is an important parameter for evaluating the covid-19 severity in pregnancy. this further could serve as a diagnostic category to differ the severity of covid-19 in pregnancy.