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   paraclinical findings in patients with breast cancer under tamoxifen treatment suffering from abnormal vaginal bleeding  
   
نویسنده ashrafganjoei tahereh ,amjadi nooshin ,taheripanah robabeh ,talayeh hamed ,talayeh maryam ,noorinasab nasim
منبع journal of obstetrics, gynecology and cancer research - 2024 - دوره : 9 - شماره : 3 - صفحه:283 -287
چکیده    Background & objective: the administration of tamoxifen to post-menopausal patients with breast cancer may lead to vaginal bleeding, necessitating a thorough understanding of associated factors. our objective was to investigate sonographic, hysteroscopic, and pathologic findings in breast cancer patients experiencing vaginal bleeding following tamoxifen use. materials & methods: in this cross-sectional study, we evaluated women with post-menopausal breast cancer reporting vaginal bleeding while undergoing tamoxifen treatment for more than six months. data collection involved a checklist encompassing ultrasonographic, hysteroscopic, and pathologic findings. results: the study included 100 patients with a mean age of 56.2 ± 2.9 years and a mean endometrial thickness of 14.5 ± 3.4 mm. notably, 25% of the patients exhibited abnormally large uterine size. ultrasonography revealed polyps and myomas in 36% and 15% of cases, respectively. positive hysteroscopy findings were observed in 72%, comprising polyps in 36%, hyperplasia in 32%, and atrophy in 4%. pathological assessment identified abnormal features in 31% as polyps, 34% as hyperplasia, 4% as atrophy, and 5% as cancerous lesions. conclusion: patients who received tamoxifen had high endometrial thickness due to endometrial polyp, it seems that clinicians can consider using hysteroscopy with dilation and curettage in these patients.
کلیدواژه ultrasonography ,hysteroscopy ,breast neoplasms ,uterine hemorrhage ,tamoxifen
آدرس shahid beheshti university of medical sciences, preventative gynecology research center (pgrc), imam hossein hospital, department of obstetrics and gynecology, iran, shahid beheshti university of medical sciences, preventative gynecology research center (pgrc), imam hossein hospital, department of obstetrics and gynecology, iran, shahid beheshti university of medical sciences, preventative gynecology research center (pgrc), imam hossein hospital, department of obstetrics and gynecology, iran, qazvin university of medical sciences, velayat medical center, iran, shahid beheshti university of medical sciences, preventative gynecology research center (pgrc), imam hossein hospital, department of obstetrics and gynecology, iran, kerman university of medical sciences, department of obstetrics and gynecology, iran
پست الکترونیکی nasim.nasab@gmail.com
 
     
   
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