comparative study between superficial and deep myometrial invasion in endometrial cancer type 1 in relation to regional lymph nodes metastasis

Background objective: the present study compares between superficial and deep myometrial invasion in type 1 endometrial cancer in relation to regional lymph nodes metastasis, so we can answer the question to do or not do lymphadenectomy, this life-threatening procedure in both superficial and deep myometrial invasion with type 1, clinically and radiologically stage 1 endometrial cancer.materials methods: patients were divided into 2 groups distributed as follows: group i includes 50 patients type 1 endometrial cancer with superficial myometrial invasion and group ii includes 50 patients type 1 endometrial cancer with deep myometrial invasion. total abdominal hysterectomy with bilateral salpingo-opherectomy with pelvic and lower para-aortic lymphadenectomy to all patients included in the study from both groups. histopathological examinations were done to all the specimen from both groups to confirm diagnosis of type 1 endometrial cancer, depth of myometrial invasion, pathological grading and metastasis to the regional lymph nodes.results: considering regional lymph nodes metastasis in both groups, there is a statistical difference between group i and group ii in relation to regional lymph nodes metastasis as group ii (cases with deep myometrial invasion) are associated with more regional lymph nodes metastasis (p= 0.0001)).conclusion: deep myometrial invasion in type 1 endometrial cancer is associated with significant increase in regional lymph nodes metastases.