>
Fa   |   Ar   |   En
   the role of thrombophilia factors polymorphism and cytogenetic analysis in recurrent pregnancy loss (rpl) in northeastern iran  
   
نویسنده javan mohammad reza ,moghimian-boroujeni bahareh ,ayatollahi hossein ,ayatollahi amirali ,amini nafise ,jafaei elham ,sheikhi maryam ,soltani narjes
منبع journal of obstetrics, gynecology and cancer research - 2023 - دوره : 8 - شماره : 4 - صفحه:342 -349
چکیده    Background objective: recurrent pregnancy loss (rpl) is the occurrence of three or more miscarriages before the 20th week of pregnancy. thrombophilia factors are one of the common causes of rpl.materials methods: this retrospective study was performed on women with miscarriages. 620 patients’ documents with pregnancy loss were investigated. based on the number of pregnancy loss, the women were divided into a control group with less than three miscarriages (212) and rpl group (180). cytogenetics analysis and thrombophilia factors polymorphism tests were performed for all patients.results: in the analysis, none of the studied polymorphisms (mthfr 677 c⁄t /factor v leiden /prothrombin g20210a/ ace i/d/ pai-1) showed a significant relationship between control and rpl groups (p-value ˃ 0.05). cytogenetic analysis showed 2 numerical and 9 structural abnormalities among both groups. statistical analysis indicated a significant association between the number of abortions and age (p value= 0.005, r= 0.139). we even realized that there was a significant relationship between polymorphism number and recurrent number of miscarriages (p value= 0.018, r= 0.6).conclusion: we showed that polymorphisms analysis for thrombophilia factors is a more precious test than cytogenetics analysis (study of the banded pattern of chromosomes during metaphase of the cell cycle). we even indicated that no association was found between thrombophilia polymorphisms in the control and rpl groups. this means that screening for factor v leiden, prothrombin g20210a, mthfr c677t, ace i/d, and pai-1 and cytogenetic analysis in patients with a history of rpl is not recommended.
کلیدواژه thrombophilia factors ,cytogenetic ,recurrent pregnancy loss ,polymorphism ,chromosomal abnormalities
آدرس iranian blood transfusion organization (ibto), blood transfusion research center, high institute for research and education in transfusion medicine, iran, ahvaz jundishapur university of medical sciences, thalassemia and hemoglobinopathy research center, health research institute, iran, mashhad university of medical sciences, cancer molecular pathology research center, department of hematopathology, iran, mashhad university of medical sciences, cancer molecular pathology research center, iran, mashhad university of medical sciences, cancer molecular pathology research center, iran, mashhad university of medical sciences, cancer molecular pathology research center, iran, mashhad university of medical sciences, cancer molecular pathology research center, iran, mashhad university of medical sciences, cancer molecular pathology research center, iran
پست الکترونیکی narjessoltanei@gmail.com
 
     
   
Authors
  
 
 

Copyright 2023
Islamic World Science Citation Center
All Rights Reserved