prevalence and correlates of the estrogen and progesterone receptors (er/pr), human epidermal growth factor receptor-2 (her-2) and p53 in breast cancer: a cross-sectional study

Background & objective: breast cancer has a pivotal role in many deaths caused by malignancies. epidermal growth factor receptor-2 (egfr-2 or her-2) and estrogen receptor (er) have immense predictive values as prognostic factors. breast cancers that have steroid receptors and respond to hormone therapy show a better prognosis than cancers without steroid receptors.materials & methods: a retrospective cross-sectional study was performed on 500 pathology blocks of women with breast cancer sent to the pathology department of amir-al-momenin medical and educational center, gerash, iran, from 2016 to 2019. data were analyzed by spss software (version-16) via anova test followed by chi-square and t-tests. p-value <0.05 was considered as significant.results: the utmost type of malignancy was invasive ductal carcinoma (idc) at 35.03%. among er-positive patients 59.67% were her-2-positive. nonetheless, among the pr-positive patients 54.74% were her-2-positive. er-positive patients were correlated with p53 receptor, distant metastasis and her-2 significantly (p<0.01). however, pr-positive patients just correlated with p53 receptor significantly (p<0.01).conclusion: investigated samples were more er-negative and less pr-positive compared to similar studies. meanwhile, er-positive patients were her-2-positive. regarding the correlation with prognosis of breast cancer, especially in her-2-positive patients, there is a need to perform profound screening programs for her-2 in breast cancer patients, especially with histopathological characteristics of invasive ductal carcinoma.