in vitro anthelmintic of glucose-based carbon quantum dots against strongyle eggs: a morphological study

Strongyle infections pose a significant threat to animal health and the development of novel therapeutic agents is crucial for effective control. in this study, we investigated the efficacy of copper-doped carbon quantum dots (cu@cqds) against strongyle infections. our results showed that cu@cqds at a concentration of 12.5 µg/ml exhibited notable efficacy in inducing structural changes in strongyle eggs, leading to deformities. the observed efficacy was likely due to the accumulation of cu@cqds around the surface of the eggs which disrupted their normal functioning. the results showed that the negative control group had a hatching rate of 92%, with 8 out of 100 eggs failing to hatch, while the positive control group had a significantly lower hatching rate of only 3%. in the cqds treatment group, the percentage of unhatched eggs was 89%, 72%, 57% and 44% at concentrations of 12.5, 6.25, 3.125 and 1.5625 µg/ml, respectively. similarly, in the cu@cqds treatment group, the percentage of unhatched eggs was 95%, 79%, 69% and 48% at the corresponding concentrations. our findings suggested that cu@cqds might be a promising therapeutic agent for combating strongyle infections and further studies are necessary to fully elucidate their mechanism of action and explore their potential applications in veterinary medicine.