clinical report of a successful treatment of mebendazole toxicity, with silymarin drug in kittens, referred to veterinary hospital of shahid chamran university of ahvaz, ahvaz, iran

Mebendazole is an anti-parasitic drug used to treat infections caused by worms and other parasites. it is given at a dose of 22 mg/kg in pets (1). a dose of several times has the risk of hepatotoxicity and in some cases death. in the present study, during the years 2022-2023, six kittens with symptoms of toxicity were referred to the department of small animal medicine. the most important clinical symptoms were illness, depression, lethargy, anorexia, saliva secretion and dehydration. toxicity with mebendazole was confirmed by clinical examination and taking history. out of six kittens, three cases were referred to the hospital less than 6 hr (group a) and other three cases, after more than 6 hr (group b). blood samples were taken and measurement of alkaline phosphatase, alanine transaminase and aspartate aminotransferase was done. supportive treatments were done in them including fluid therapy and administration of group b vitamins. concurrently, they were treated with silymarin (livergol) at a dose of 30 mg/kg (only once). in group a, liver enzymes returned to normal range within 48 hr, whereas in group b, liver enzymes were still high up to 96 hr and the process of treatment was longer. this study showed that early silymarin treatment correlated with quicker recovery. it is recommended to study on more animals and longer enzyme monitoring periods to fully understand silymarin s effects in treating mebendazole toxicity.