investigating the role of quercetin as an antioxidant in degenerative diseases: a review abstract

Cancer poses a major global challenge due to increasing incidence rates and limited treatment options. thus, discovering new therapeutic targets and identifying potential therapeutic molecules for tumor treatment is crucial. diet is crucial for maintaining health with natural products like flavonoids playing a role in cancer prevention. flavonoids are plant-derived natural antioxidants found in fruits and vegetables, where they help trap free radicals. quercetin, a notable bioactive flavonoid has garnered attention for its various health benefits. it is present in many foods including fruits, seeds, vegetables, tea, coffee, bracken fern, and natural dyes. quercetin may protect against degenerative diseases by inhibiting lipid peroxidation. the extent and mechanism of quercetin in vivo absorption remain largely unknown. the primary glucoside form is thought to be converted into the aglycone which is then transformed into various quercetin metabolites. studying quercetin metabolites is crucial for understanding its antioxidant mechanism. multiple studies both in vivo and in vitro support its potential as an anticancer agent. quercetin strong toxicity against cancer cells is linked to minimal or no side effects on normal cells. in recent decades, quercetin has been recognized for its anticancer properties including its involvement in cell signaling, pro-apoptotic activity, anti-proliferative effects, antioxidant capabilities and growth suppression. it is now understood that quercetin exerts various biological effects by inhibiting multiple enzymes involved in cell proliferation and signal transduction pathways. this review briefly discusses quercetin chemical and physical properties as well as its antioxidant and anticancer activities and mechanisms of action.