effects of linalool on oxidative stress parameters in a rat model of cutaneous wound healing

Chronic and non-healing skin wounds have consistently posed a financial burden on patients, insurance providers, and governments (1). this study aimed to investigate the beneficial effects of linalool on oxidative stress parameters in wound healing in rats. linalool is a monoterpene alcohol present in various aromatic plant species with the most common plant families being lamiaceae, lauraceae, and apiaceae. it has some beneficial effects including anti-inflammatory, anticancer, lipid-lowering, sedative, antimicrobial, antidepressant and neuroprotective properties (2,3). male mice (n = 24) were divided into three groups: 1-sham: the wound was created using an 8 mm skin biopsy punch with no treatment. 2- soyabean: the wound was created and soyabean oil was applied on the wound daily for 9 days. 3- linalool group: after wound creation, linalool+soybean was rubbed on the wound daily for 9 days. on day 14, the animals were sacrificed and skin samples were taken and malondialdehyde (mda), total oxidant status (tos), glutathione peroxidase (gpx) and total antioxidant capacity (tac) were evaluated. linalool significantly reduced the levels of mda and tos compared to the sham and soybean groups (p < 0.05). levels of gpx were increased in linalool group compared to other groups nonsignificantly (p > 0.05). moreover, tac levels were significantly increased in the treatment group compared to other groups (p < 0.05). overall, linalool treatment could beneficially reduce oxidative stress and improved wound healing compared to the sham and soyabean groups. therefore, topical administration of linalool could be recommended for wound healing due to reducing oxidative stress biomarkers and wound healing acceleration.