the effect of the pharmacological effects of sulfasalazine and hydroalcoholic extract of the ivy plant on ulcerative colitis in wistar rats experimental model

Following acquiring the ivy plant, we cleaned it and dried it in a sanitary environment at room temperature. after one week, we filtered the resulting solution multiple times to eliminate plant residues. the rats were kept in a state of fasting for 24 hr, after which we induced ulcerative colitis using an acetic acid solution administered via an injector (1). there was a significant reduction in the disease severity index in the treatment group receiving ivy extract at doses of 50 and 100 mg, however, no statistically significant difference was observed between these two doses. conversely, the group treated with 150 mg of ivy extract demonstrated a notable decrease in the disease severity index, exhibiting a significant difference from the other groups. the activity of the mpo enzyme and nitric oxide was the highest in the affected group and the lowest in the healthy group. a reduction in enzyme levels was observed in the treatment group receiving sulfasalazine, although there was no significant difference between the affected group and the 50 mg extract treatment group. however, no significant differences were found between the treatment groups receiving 100 mg and 150 mg. there was no significant relationship between the various concentrations of ivy extract except for il-1 where the optimal concentration was determined to be 100 mg. based on these findings, it coul be concluded that ivy extract could control inflammation and manage ulcerative colitis (2,3).