evaluation of the number of mast cells in lung tissue in offspring from pregnant rats poisoned by paraquat and protective effects of coenzyme q10

Paraquat may cause acute respiratory distress syndrome, being determined by collagen deposition and pulmonary fibrosis leading to a decrease in expansion and vital capacities (1). it has been determined that mast cells number increases in the pulmonary interstitial tissue of humans and animals with pulmonary fibrosis. it has been indicated that mast cells can play a role in pulmonary fibrosis through fibroblast activation (2). the current study aimed to examine pulmonary mastocytosis in the infants of pregnant rats poisoned with paraquat and the possible protective effects of coenzyme q10. paraquat caused a significant increase in mast cells population of lung tissue, indicating that paraquat causes pulmonary mastocytosis in infants rats whose mothers have been administered paraquat during pregnancy. while, the average number of mast cells in the group received coenzyme q10 plus paraquat decreased significantly compared to the paraquat-treated group. it can be suggested that paraquat may cause pulmonary fibrosis through mastocytosis induction and coenzyme q10 can have pulmonoprotective effects via mastocytosis inhibition.