effects of gallic acid on kim-1, ifn-γ and ppar-γ levels on acrylamide-induced kidney damage in rats

Acrylamide (acr) is a chemical that is widely used in many areas and can cause damage to many tissues and organs. it occurs as a result of heat treatment of foods containing mainly carbohydrates and proteins. in this study, the effects of gallic acid (ga) on kidney damage induced by acr were investigated. a total of 40 male sprague dawley rats were used in this study and the rats were divided into five experimental groups including control, acr, acr+ga50, acr+ga100 and ga100. in the experiment, acr was applied to the acr groups at a dose of 50 mg/kg, while ga was applied to the ga groups at doses of 50 and 100 mg/kg. at the end of the 14-day experiment, the rats were euthanized and their kidney tissues were removed. the level of kidney injury molecule-1 (kim-1), a marker of damage in kidney tissue, was determined by elisa method. also, in order to determine whether inflammation developed in kidney tissues taken from rats, the interferon-γ (ifn-γ) and peroxisome proliferator-activated receptor gamma (ppar-γ) levels were determined using the elisa method. while both kim-1 and ifn-γ levels increased significantly in the groups treated with acr, there was a decrease in the kidney tissues of the treated rats with ga. the ppar-γ levels also indicated that acr induced marked nephrotoxicity. as a result, in this study it was determined that ga had a protective effect against acr-induced renal inflammation and this protective effect was achieved especially with high doses of ga.