in vivo evaluation of superoxide dismutase and histopathological analysis of the large intestine in quinolone-treated wistar rats

The use of quinolone natural compounds has been well-established for almost a century and is associated with various therapeutic purposes, showing protective effects. among the quinolone-class drugs, ciprofloxacin, a widely used medication, has demonstrated anti-oxidant effects. in this study, the focus was on investigating the anti-oxidant levels, specifically superoxide dismutase (sod), in the large intestine, along with histopathological assessment. the study involved twelve male wistar rats divided into two groups including a control group received 1 ml of distilled and deionized water twice a week via gavage and a ciprofloxacin group received 1 ml of ciprofloxacin at a dose of 70 mg/kg twice a week over a span of 8 weeks. following the 8-week period, all rats were sacrificed for histopathological evaluation and sod measurement. the results showed a significant increase in the sod levels in the large intestine of the ciprofloxacin-treated group compared to the control group. moreover, normal histopathological conditions were observed in the colon of all groups. the findings of this study suggest that ciprofloxacin treatment could potentially elevate the anti-oxidant levels in organ tissues, indicating its potential use as a novel therapeutic agent in clinical trials.