electrochemical investigation of drug interaction of epinephrine with captopril in aqueous solution

Abstract: drug-drug interaction are the most common type of drug interaction. these types of drug interaction can increase minor or serious unexpected side effects, may decrease performance of medications, or the most important one is increasing the blood level and possible toxicity of a certain drug. in recent years, studies in this field by using different techniques have become more important. epinephrine is a hormone that is naturally released when a person experiences high excitement and stress, and also it is a medication which is used in emergency medical treatment for increasing blood pressure [1]. due to that the disease of hypertension and being in a stressful situation is very common in today societies. captopril is a drug that is now used in all age groups to treat high blood pressure as an available and affordable drug [2]. in this study, the electrochemical behavior of epinephrine in the presence of captopril was investigated using cyclic voltammetry and controlled-potential coulometry techniques in an aqueous buffer solution (ph~7). the results indicated that the peak structures and currents have changed and captopril has decreased the epinephrine current value in cyclic voltammetry. corresponding products were electrochemically synthesized in aqueous solutions using a carbon electrode in a divided cell. these products were identified by spectroscopic methods (ft-ir, 1hnmr, and13cnmr).