glassy carbon electrode modification with a molecularly imprinted polymer by electropolymerization method for preparation of a valsartan sensor

Abstract: in this study, an electrochemical sensor based on the electropolymerization of orthophenylene diamine (o-pd) on a glassy carbon electrode (gce) for measuring valsartan was proposed. the measurement is based on the reduction of the oxidation-reduction pair [fe(cn)6]3- /[fe(cn)6]4- due to the occupation of the valsartan complexing sites [1]. under optimal conditions (buffer solution with ph 5, extraction time 10 minutes, valsartan concentration 1 mm, monomer concentration 5 mm, scan speed 50mv/s, number of polymerization 10, number of engraved scans 50 and duration of drug application is 20 minutes). using cyclic voltammetry and differential pulse voltammetry, the change in current was obtained linearly with a concentration of valsartan in the range of 0.1 to 10 mg/l and a detection limit of 0.001 mg/l. the effect of disturbance for the proposed sensor was studied by determining valsartan in solutions containing valsartan / amylodepine, valsartan / ascorbic acid, valsartan / urea, valsartan / glucose. the construction of this sensor is very simple and cost-effective, and the detection limit obtained is much lower than other methods.