determination and extraction of fluoxetine antidepressant drug using dispersive liquid-liquid microextraction coupled with solid phase evaporation followed by corona discharge ionization-ion mobility spectrometer apparatus

The mcm-41@sio2 solid phase was used as a porous adsorbent for preconcentration of fluoxetine antidepressant drug (as a model compound) and totally evaporation of the extraction solvents obtained by dispersive liquid liquid microextraction method. to detect of the analyte molecules, corona discharge ionization-ion mobility spectrometer (cd-ims) was applied. the mcm-41@sio2 was synthesized as an adsorbent for coating on the solid phase fiber. in order to increase the extraction efficiency of the fluoxetine drug, some variables including, extraction solvent and its volume, disperser solvents and its volume, sample solution ph, desorption temperature, and evaporation time of the solvent from the solid phase fiber were chosen and optimized. some analytical parameters including, limit of detection (lod), limit of quantification (loq), linear dynamic range (ldr) with determination coefficient, and relative standard deviations (rsds) were calculated at the optimized conditions. the lod (s/n=3); 3 µg l-1, loq (s/n=10); 10 µg l-1, ldr; 10-200 µg l-1, intra- and inter-day rsds (n=3); 2.5%, 9.6% for 10 µg l-1, 1.8%, 7.7% for 150 µg l-1, respectively. to investigate the ability of the hyphenated method, some biological samples such as human urine, blood plasma, and saliva samples were selected and the relative recovery values were calculated.